DISPOSITION KINETICS OF PANCURONIUM BROMIDE IN PATIENTS WITH TOTAL BILIARY OBSTRUCTION
نویسندگان
چکیده
منابع مشابه
Disposition kinetics of pancuronium bromide in patients with total biliary obstruction.
Plasma concentrations of pancuronium were measured in nine patients undergoing surgery because of total biliary obstruction. When compared with the averaged model-independent pharmacokinetic parameters obtained for normal patients, the terminal half-life of 270 min was more than twice normal (132 min, P less than 0.001); the plasma clearance of 59 ml min-1 was less than half the normal rate for...
متن کاملMyocardial stimulation by pancuronium bromide.
The effect of pancuronium bromide on the canine myocardium was studied by observing several indices of myocardial contractility during i.v. and intracoronary infusion of the drug in an anaesthetized, open-chested dog preparation. Pancuronium produced tachycardia when given for 2 min by i.v. and intracoronary infusion with the heart intact. Following denervation and pacing of the heart the intra...
متن کاملComparative potency of pipecuronium bromide and pancuronium bromide.
Cumulative dose-response curves were constructed to determine the comparative potency of pipecuronium and pancuronium. From these, the ED50 and ED95 values were calculated. These were 24.96 micrograms kg-1 and 44.96 micrograms kg-1, respectively, for pipecuronium and 30.42 micrograms kg-1 and 61.12 micrograms kg-1, respectively, for pancuronium.
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1977
ISSN: 0007-0912
DOI: 10.1093/bja/49.11.1103